Seven Danish Scientists visited Fujian Institute of Research on the Structure of Matter (FJIRSM), Chinese Academy of Sciences in February, 2009. A seminar was held in the Physics Building of FJIRSM on February 9th, establishing the Joint Research Center on Protease and Cancer. The meeting was attended by Professor Peter Andreasen (Department of Molecular Biology, University of Aarhus, Denmark); Dr. Michael Ploug and Dr. Niels Behrend (Finsen Laboratory, Copenhagen, Denmark); Dr. Jorgen Kjems and Dr. Niels Christian Nielsen (the Interdisciplinary Nano Science center, University of Aarhus, Denmark); Dr. Andreas Kjor (School of Medicine, Copenhagen University); Professor Rong Cao (Deputy director in FJIRSM); Professor Mingdong Huang and Zhuo Chen (Research Center of Biochemistry in FJIRSM). The research objectives of this Center are: 1. Develop specific inhibitors for proteolytic enzyme system by the ways of directed evolution and structure-based rational drug design. 2. Determine the three-dimensional structures of target protein and complexes of the target protein and their inhibitors. 3. Test the therapeutic effects of these inhibitors via animal tumor model. 4. Design molecular that can combine with anti-cancer drugs and enhance their specificity for tumor and metastases by using extracellular proteolytic enzyme as the pro-and molecular. 5. Develop methods for predicting primary cancer and potential metastases through the semi-quantitative non-invasive imaging technology in order to optimize applications of the enzyme system in diagnostic information science. 　　

Professor Peter A. Andreasen, Director of the Department of Molecular Biology, University of Aarhus in Denmark, is currently a commissioner of European Research Fund Vetting Committee, the Danish Cancer Research Fund Committee, Italy and other countries Research Fund Committee invited jury and more than University job title Accreditation Committee, and served as deputy editor, editorial board member or guest reviewers in more than 30 internationally renowned journals including "Journal of Thrombosis and Hemostasis". His research area involves many aspects of biochemistry, cell biology and tumor biology. He is the one who took the lead in the plasminogen activator inhibitor 1 (PAI-1) cDNA cloning, and the one who first advanced a new theory that PAI-1 can be used as a marker in cancer prognosis. 　　

The backbone Chinese scholar of the Center is Prof. Mingdong Huang, doctoral supervisor, who is a research professor with the State Key Laboratory of Structural Chemistry. At present, Prof. Huang is the director of the Research Center of Biochemistry, FJIRSM, winner of the Distinguished Youth Award of the National Natural Science Foundation (NNSF),. His main research interests include structural biology and biochemistry. Prof. Huang has ever published some influential research papers on several internationally well-known scientific periodicals such as Science and Nature.