Prof. LIU Xiaolong----Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Prof. Xiaolong Liu

Office Phone: +86-592-3594010

Homepage of Liu’s Group: http://www.xmirem.ac.cn/kydw/kytd/ktz3_37068/ktz3_ktzjj/

Prof. Xiaolong Liu received his Ph.D. degree in Biological Physics from School of Life Science and Technology, Xi’an Jiaotong University (Shanxi, China) in 2008 following the joint doctoral experience majoring in Biochemistry and Molecular Biology from the Surgical Research Center of Brown University (Rhode Island, USA). From 2008 to 2010, he worked in the Surgical Research Center of Brown University and Biozentrum, University of Basel (Switzerland) as a Postdoc. From 2010 to 2013, he was appointed as a Research Associate (Staff Scientist) in Biozentrum, University of Basel; from 2013 to now, he was appointed as a full professor and the vice president of Mengchao Hepatobiliary Hospital of Fujian Medical University (Fujian, China). Since 2017, he has been appointed as part-time professor and PI at Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences. His research activities involve in developing novel strategies for early diagnosis and therapy of cancer, molecular imaging and imaging guided surgery, cancer immunotherapy and precision medicine based on nanotechnologies.

Introduction of Liu’s Group

Focusing on the clinical demands of precision cancer diagnosis and therapy, his research group emphasizes the using of synthetic biotechnology, biomedical strategy, nanotechnology and biomaterials to focus on the basic and translation studies of tumor molecular imaging and imaging guide surgery, tumor specific theranostic probes, tumor microenvironment imaging and manipulation, cancer immunotherapy (neoantigen based nano-vaccine and engineered immune cells). The group has published more than 80 papers in the world recognized journals including ACS Nano, Clinical Cancer Research, Theranostics, Journal of Controlled Release, Advanced Science, with more than 1000 citations in recent 3 years.

Representative Publications:

1. Li Y#, Lin J#, Cai Z, Wang P, Luo Q, Yao C, Zhang Y, Hou Z, Liu J*, Liu X*. Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy. J Control Release. 2020，321:222-235.

2. Z Cai#, F Xin#, Z Wei, M Wu, X Lin, Xi Du, G Chen, D Zhang, Z Zhang, X Liu*，and C Yao*. Photodynamic therapy combined with anti-hypoxic signaling and CpG adjuvant as in-situ immunostimulant based on Metal-Organic Framework nanoparticles to boost cancer immunotherapy. Advanced Healthcare Materials, 2019, DOI: 10.1002/adhm.201900996.

3. Li Y#, Lin J#, Wang P, Luo Q, Lin H, Zhang Y, Hou Z, Liu J*, Liu X*. Tumor Microenvironment Responsive Shape-Reversal Self-Targeting Virus-Inspired Nanodrug for Imaging-Guided Near-Infrared-II Photothermal Chemotherapy. ACS Nano. 2019, DOI: 10.1021/acsnano.9b05425.

4. Zhang D, Zheng Y, Lin Z, Lan S, Zhang X, Zheng A, Li J, Liu G, Yang H, Liu X*, and Liu J*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as a Powerful Strategy for Enhancing Photothermal-Immunotherapy Efficiency of Solid Tumors. Small. 2019, 15(42):e1902636. doi: 10.1002/smll.201902636.

5. Z Cai, G Chen, Y Zeng, X Dong, Z Li, Y Huang, F Xin, L Qiu, X Liu* and J Liu*. Comprehensive liquid profiling of circulating tumor DNA and protein biomarkers in long-termed follow-up patients with hepatocellular carcinoma. Clinical Cancer Research, 2019, DOI: 10.1158/1078-0432.CCR-18-3477.

6. D Zhang, C Zhang, S Lan, Y Huang, J Liu, J Li*, X Liu* and H Yang*. Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small, 2019, 1901176, 1-10.

7. B Zhao#, Y Wang#, X Tan, K Ke, C Zhang, Y Gao, N Liao, Y Dang, Y Shi, Y Zheng, X Liu*, and J Liu*. An optogenetic engineered SUPER-T cell for hepatocellular carcinoma therapy. Theranostics, 2019, 9(7):1837-1850.

8. P Wang, X Wang, Q Luo, Y Li, X Lin, L Fan, Y Zhang, J Liu *, and X Liu*. Fabrication of Red Blood Cell Based Multi-model Theranostic Probes for the Second Near-infrared Window Fluorescent Imaging-guided Tumor Surgery and Photodynamic Therapy. Theranostics, 2019, 9(2), 369-380.

9. D Zhang, Z Cai, N Liao, S Lan, M Wu, H Sun, Z Wei, J Li*, and X Liu*. pH / Hypoxia Programmable Triggered Cancer Photo-Chemotherapy Based on Semiconducting Polymer dot hybridized Mesoporous Silica Framework. Chemical Science, 2018, 9(37):7390-7399.

10. D Zhang, M Wu, Z Cai, N Liao, K Ke, H Liu, M Li, G Liu, H Yang, X Liu*, and J Liu*. FDA approved drug based metal-organic particles for microvesicle-mediated deep penetration and pH / NIR / hypoixa-programmable activated cancer photo-chemotherapy. Advanced Science, 2018, 5(2):1700648, DOI: 10.1002/advs.201700648.

11. D Zhang, A Zheng, J Li, M Wu, Z Cai, L Wu, Z Wei, H Yang, X Liu*, and J Liu*. Tumour micro-environment activitable self-assembled DNA hybrids for pH and redox dual-responsive chemotherapy / PDT treatment of Hepatocellular carcinoma. Advanced Science, 2017, 1600460, DOI: 10.1002/advs.201600460.